- Title
- Hypoxia-inducible factor (HIF) as a target for novel therapies in rheumatoid arthritis
- Creator
- Hua, Susan; Dias, Thilani H.
- Relation
- Frontiers in Pharmacology Vol. 7, no. 184
- Publisher Link
- http://dx.doi.org/10.3389/fphar.2016.00184
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2016
- Description
- Hypoxia is an important micro-environmental characteristic of rheumatoid arthritis (RA). Hypoxia-inducible factors (HIF) are key transcriptional factors that are highly expressed in RA synovium to regulate the adaptive responses to this hypoxic milieu. Accumulating evidence supports hypoxia and HIFs in regulating a number of important pathophysiological characteristics of RA, including synovial inflammation, angiogenesis, and cartilage destruction. Experimental and clinical data have confirmed the upregulation of both HIF-1α and HIF-2α in RA. This review will focus on the differential expression of HIFs within the synovial joint and its functional behavior in different cell types to regulate RA progression. Potential development of new therapeutic strategies targeting HIF-regulated pathways at sites of disease in RA will also be addressed.
- Subject
- rheumatoid arthritis; hypoxia; hypoxia-inducible factor; inflammation; synovitis; angiogenesis; cartilage degradation; targetedtherapy
- Identifier
- http://hdl.handle.net/1959.13/1346241
- Identifier
- uon:29816
- Identifier
- ISSN:1663-9812
- Rights
- © 2016 Hua and Dias. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
- Language
- eng
- Full Text
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